Drug General Information
Drug ID	D00TVI
Former ID	DIB015118
Drug Name	SR-58894A
Indication	Gastrointestinal disease [ICD10:K00-K93]		Terminated	[546455]
Company	Sanofi-Synthelabo
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12[C@@H](NC[C@@H](COc3c(CC=C)cccc3)O)CCCc1cccc2.Cl
CAS Number	CAS 132017-03-9
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[527168]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546455	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008218)
Ref 527168	Pharmacological characterization of beta-adrenoceptor subtypes mediating relaxation in porcine isolated ureteral smooth muscle. J Urol. 2004 Sep;172(3):1155-9.

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