Drug General Information
Drug ID	D00VYD
Former ID	DIB020861
Drug Name	RS-136270
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542752]
Structure		Download 2D MOL
Formula	C12H10ClNO2
InChI	InChI=1S/C12H10ClNO2/c13-10-4-1-3-9(7-10)8-14-6-2-5-11(14)12(15)16/h1-7H,8H2,(H,15,16)
InChIKey	VPTUTBZAHHDMAA-UHFFFAOYSA-N
PubChem Compound ID	5071702
PubChem Substance ID	15267671, 24322078, 79496308, 113697180, 121149530, 135650940, 147960268, 237960117
Target and Pathway
Target(s)	C-C chemokine receptor type 2	Target Info	Antagonist	[525750]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Leptin Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Beta defensins
	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Defensins
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542752	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 780).
Ref 525750	J Biol Chem. 2000 Aug 18;275(33):25562-71.Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helicalbundle.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.