Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00VZF
|
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| Former ID |
DIB007605
|
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| Drug Name |
Merbarone
|
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| Synonyms |
NSC-336628
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| Drug Type |
Small molecular drug
|
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| Indication | Pancreatic cancer [ICD9: 140-199, 140-229, 157, 210-229; ICD10:C25] | Discontinued in Phase 2 | [1] | ||
| Company |
Uniroyal Chemical Co Inc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C11H9N3O3S
|
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| Canonical SMILES |
C1(=O)NC(=S)NC(=O)C1C(=O)Nc1ccccc1
|
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| CAS Number |
CAS 97534-21-9
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA topoisomerase II | Target Info | Modulator | [2] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000894) | ||||
| REF 2 | The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication. Mutat Res. 2012 Oct-Nov;738-739:45-51. | ||||
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