Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00VZZ
|
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| Former ID |
DNC012876
|
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| Drug Name |
ALLOPREGNANOLONE
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
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| Formula |
C21H34O2
|
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| InChI |
InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
|
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| InChIKey |
AURFZBICLPNKBZ-SYBPFIFISA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
586301, 7978606, 10225577, 12208574, 14826064, 14923739, 24278659, 44423581, 47513077, 47586678, 49836635, 50019556, 57335345, 74846894, 85300819, 85788331, 87550959, 92298224, 93167087, 95613568, 103489280, 104074460, 104408358, 124583834, 124892416, 126524062, 126688946, 127461832, 134350081, 135049778, 144205595, 144238831, 162089001, 178100930, 179236194, 184545674, 198958618, 198993875, 223672111, 224946688, 226892359, 241204043
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| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [527511] | |
| Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [528321] | ||
| Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [527511] | ||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [527511] | ||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
| Iron uptake and transport | |||||
| References | |||||
| Ref 467451 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4108). | ||||
| Ref 524035 | ClinicalTrials.gov (NCT01673828) Allopregnanolone for the Treatment of Traumatic Brain Injury. U.S. National Institutes of Health. | ||||
| Ref 527511 | J Med Chem. 2005 Apr 21;48(8):3051-9.Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)-and (3alpha,5beta)-3-hydroxypregnan-20-one. | ||||
| Ref 528321 | J Med Chem. 2006 Jul 27;49(15):4595-605.Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. | ||||
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