Drug Information

Drug General Information
Drug ID
D00WDY
Former ID
DIB007364
Drug Name
BMS-903452
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 1 [523251]
Company
Bristol-Myers Squibb Co
Structure
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2D MOL

3D MOL
Target and Pathway
Target(s) Glucose-dependent insulinotropic receptor Target Info Modulator [532950]
KEGG Pathway cAMP signaling pathway
Insulin secretion
WikiPathways Incretin Synthesis, Secretion, and Inactivation
References
Ref 523251ClinicalTrials.gov (NCT01240980) Safety Study of BMS-903452 in Healthy Subjects (Panel 1-7) & Relative Bioavailability of the Crystalline and Amorphous Forms of BMS-903452 [Panels 4, 6, 11 & 12(Part A)], and Subjects With Type 2 Diabetes Mellitus (Part B). U.S. National Institutes of Health.
Ref 532950Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119. J MedChem. 2014 Sep 25;57(18):7499-508.

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