Drug General Information
Drug ID	D01BVR
Former ID	DNC006216
Drug Name	5-(4-piperidyl)-4-propylisothiazol-3-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528034]
Structure		Download 2D MOL 3D MOL
Formula	C11H18N2OS
Canonical SMILES	CCCC1=C(SNC1=O)C2CCNCC2
InChI	1S/C11H18N2OS/c1-2-3-9-10(15-13-11(9)14)8-4-6-12-7-5-8/h8,12H,2-7H2,1H3,(H,13,14)
InChIKey	INIXNNKFVDXPBJ-UHFFFAOYSA-N
PubChem Compound ID	11515063
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528034]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528034]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528034]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 528034	J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Ref 528034	J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.

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