Drug Information

Drug General Information
Drug ID
D01BXE
Former ID
DIB019147
Drug Name
CITCO
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539803]
Structure
Download
2D MOL
Formula
C19H12Cl3N3OS
InChI
InChI=1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
InChIKey
ZQWBOKJVVYNKTL-AUEPDCJTSA-N
PubChem Compound ID
9600409
PubChem Substance ID
854372, 7886607, 17396629, 24016238, 24724448, 25795375, 26756451, 26756452, 26756453, 26758472, 29216414, 44736028, 47498114, 48093098, 48317021, 48392500, 50111366, 50267643, 53790778, 57373266, 85287714, 85787274, 89714607, 92310050, 99300962, 99302482, 103647957, 109634513, 135337076, 135697963, 162248406, 163688364, 187071860, 198935661, 223369972, 226591793, 241071559, 252157451, 252343227, 252455774
Target and Pathway
Target(s) Orphan nuclear receptor NR1I3 Target Info Agonist [526558]
Pathway Interaction Database Glucocorticoid receptor regulatory network
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Constitutive Androstane Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
References
Ref 539803(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2758).
Ref 526558Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem. 2003 May 9;278(19):17277-83. Epub 2003 Feb 27.

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