Drug Information

Drug General Information
Drug ID
D01CSM
Former ID
DIB018355
Drug Name
[3H]nelivaptan
Synonyms
[3H]-SSR149415; [3H]SSR149415
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540423]
Structure
Download
2D MOL
Formula
C30H32ClN3O8S
InChI
InChI=1S/C30H32ClN3O8S/c1-32(2)28(36)24-15-19(35)17-33(24)30(21-8-6-7-9-25(21)41-4)22-14-18(31)10-12-23(22)34(29(30)37)43(38,39)27-13-11-20(40-3)16-26(27)42-5/h6-14,16,19,24,35H,15,17H2,1-5H3/t19-,24+,30+/m1/s1/i3T3,5T3
InChIKey
NJXZWIIMWNEOGJ-KGKCFUOPSA-N
PubChem Compound ID
70692936
PubChem Substance ID
160696668, 178100474
Target and Pathway
Target(s) Vasopressin V1b receptor Target Info Antagonist [543797]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540423(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3483).
Ref 543797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 367).

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