Drug General Information
Drug ID	D01EPO
Former ID	DIB016016
Drug Name	ABIO 09-01
Synonyms	Antidepressants, Abiogen; BTG-1675A
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Investigative	[543440]
Company	BTG plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1CCC=C(C1=O)C1N(CCOC1)O
Target and Pathway
Target(s)	CaM kinase II	Target Info	Inhibitor	[543440]
KEGG Pathway	ErbB signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	HIF-1 signaling pathway
	Oocyte meiosis
	Adrenergic signaling in cardiomyocytes
	Wnt signaling pathway
	Circadian entrainment
	Long-term potentiation
	Neurotrophin signaling pathway
	Cholinergic synapse
	Dopaminergic synapse
	Olfactory transduction
	Inflammatory mediator regulation of TRP channels
	Insulin secretion
	GnRH signaling pathway
	Melanogenesis
	Oxytocin signaling pathway
	Glucagon signaling pathway
	Gastric acid secretion
	Amphetamine addiction
	Tuberculosis
	Proteoglycans in cancer
	Glioma
Reactome	HSF1-dependent transactivation
	Trafficking of AMPA receptors
	Ca2+ pathway
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	CREB phosphorylation through the activation of Ras
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascade
	Interferon gamma signaling
WikiPathways	ErbB Signaling Pathway
	Calcium Regulation in the Cardiac Cell
	EGF/EGFR Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	Corticotropin-releasing hormone
	B Cell Receptor Signaling Pathway
References
Ref 543440	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1558).
Ref 543440	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1558).

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