Drug Information

Drug General Information
Drug ID
D01FGR
Former ID
DAP000490
Drug Name
Diphenhydramine
Synonyms
Aleryl; Alledryl; Allerdryl; Allergeval; Allergical; Allergina; Allergival; Amidryl; Antistominum; Antitussive; Antomin; Automin; Bagodryl; Banophen; Baramine; Beldin; Belix; Bena; Benachlor; Benadrin; Benadryl; Benapon; Benhydramin; Benodin; Benodine; Benylan; Benylin; Benzantine; Benzhydramine; Benzhydraminum; Benzhydril; Benzhydroamina; Benzhydryl; Betramin; Compoz; Dabylen; Debendrin; Dermistina; Dermodrin; Desentol; Diabenyl; Diabylen; Dibendrin; Dibenil; Dibondrin; Difedryl; Difenhidramina; Difenhydramin; Difenidramina; Dihidral; Dimedrol; Dimedryl; Dimehydrinate; Diphantine; Diphen; Diphenhist; Diphenhydraminum; Diphenylhydramin; Diphenylhydramine; Dryistan; Drylistan; Dylamon; Etanautine; Genahist; Histaxin; Hyadrine; Hydramine; Hyrexin; Ibiodral; Medidryl; Mephadryl; Nausen; Novamina; Probedryl; Restamin; Rigidil; Siladryl; Silphen; Syntedril; Syntodril; Allergan B; Allermax Caplets; BENADRYL HCl; Banophen Caplets; Benadryl Allergy; Difenidramina [Italian]; Dimedrol base; Diphen Cough; Diphenhist Captabs; Diphenhydramine Base; Diphenhydramine HCl; Nytol Quickcaps; Nytol Quickgels;Twilite Caplets; Unisom Sleepgels Maximum Strength; Dormarex 2; FAR 90X2; PM 255; S51; Aller-Med; Ben-allergin; Benadryl (TN); Benadryl (hydrochloride); Beta-Dimethylaminoethanol diphenylmethyl ether; Beta-Dimethylaminoethylbenzhydrylether; Beta-dimethylaminoethyl benzhydryl ether; Difenhidramina [INN-Spanish]; Dimedrol (TN); Diphenhydraminum [INN-Latin]; Nervine Nighttime Sleep-Aid; Nytol (TN); O-Benzhydryldimethylaminoethanol; Restamin (TN); Sleep-Eze D; Sleep-Eze D Extra Strength; DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE; Diphenhydramine (JP15/INN); Diphenhydramine [INN:BAN:JAN]; Alpha-(2-Dimethylaminoethoxy)diphenylmethane; N-(Benzhydryloksy-etylo)dwumetyloamina; N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]; Beta-Dimethylamino-aethyl-benzhydryl-aether; Beta-Dimethylamino-aethyl-benzhydryl-aether [German]; N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride; N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE; N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride; 2-(Diphenylmethoxy)-N,N-dimethylethylamine; 2-(diphenylmethoxy)-N,N-dimethylethanamine; 2-Diphenylmethoxy-N,N-dimethylethylamine; 2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine; 2-benzhydryloxy-N,N-dimethylethanamine; 2-benzhydryloxyethyl-N,N-dimethylammonium; 2-diphenylmethoxy-N,N-demthylethanamine; 2PM
Drug Type
Small molecular drug
Indication Vertigo's disease; Meniere's disease [ICD10:H81.09] Approved [551871]
Therapeutic Class
Antiallergic Agents
Company
Johnson & Johnson
Structure
Download
2D MOL

3D MOL
Formula
C17H21NO
InChI
InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
InChIKey
ZZVUWRFHKOJYTH-UHFFFAOYSA-N
CAS Number
CAS 58-73-1
PubChem Compound ID
3100
PubChem Substance ID
9174, 511392, 608048, 3154507, 5021578, 7847366, 7849634, 7885212, 7979103, 8151972, 10508422, 10528411, 10544720, 11111059, 11111060, 11335543, 11360782, 11363874, 11366436, 11368998, 11371539, 11374238, 11377160, 11407308, 11427137, 11461754, 11466093, 11467213, 11484697, 11485906, 11488777, 11490216, 11492335, 11494794, 14749996, 25768169, 26713829, 26751623, 29222243, 46505484, 47440177, 47588927, 47810670, 47810671, 48035032, 48110379, 48110380, 48184925, 48184926, 48415909
SuperDrug ATC ID
D04AA32; R06AA02
SuperDrug CAS ID
cas=000058731
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [534958], [536700]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534958Histamine as an autocrine regulator of leukemic cell proliferation. Leuk Lymphoma. 2000 Jan;36(3-4):367-73.
Ref 536700Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.