Drug Information

Drug General Information
Drug ID
D01FGW
Former ID
DNC014284
Drug Name
6-bromo-N-(3-bromophenyl)quinazolin-4-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530473]
Structure
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2D MOL

3D MOL
Formula
C14H9Br2N3
Canonical SMILES
C1=CC(=CC(=C1)Br)NC2=NC=NC3=C2C=C(C=C3)Br
InChI
1S/C14H9Br2N3/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,(H,17,18,19)
InChIKey
GBBRIESLSQOJQX-UHFFFAOYSA-N
PubChem Compound ID
46879644
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530473]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.

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