TTD | Drug: D01HUN

Drug General Information
Drug ID	D01HUN
Former ID	DIB021141
Drug Name	UR-PG131A
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538709]
Structure		Download 2D MOL
Formula	C19H21F2N7O
InChI	InChI=1S/C19H21F2N7O/c20-15-4-3-12(8-16(15)21)14(18-24-6-7-25-18)9-17(29)28-19(22)26-5-1-2-13-10-23-11-27-13/h3-4,6-8,10-11,14H,1-2,5,9H2,(H,23,27)(H,24,25)(H3,22,26,28,29)
InChIKey	DGJMWXIXZSWRLP-UHFFFAOYSA-N
PubChem Compound ID	25149704
PubChem Substance ID	103649427, 135651298, 163362207
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Agonist	[527955]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538709	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1198).
Ref 527955	Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. Epub 2006 Jan 4.

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Drug Information