Drug General Information
Drug ID	D01HZN
Former ID	DNC007663
Drug Name	1,2-bis(3,4,5-trifluorophenyl)-2-hydroxyethanone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528766]
Structure		Download 2D MOL 3D MOL
Formula	C14H6F6O2
Canonical SMILES	C1=C(C=C(C(=C1F)F)F)C(C(=O)C2=CC(=C(C(=C2)F)F)F)O
InChI	1S/C14H6F6O2/c15-7-1-5(2-8(16)11(7)19)13(21)14(22)6-3-9(17)12(20)10(18)4-6/h1-4,13,21H
InChIKey	BBOPAMQNZSQMGE-UHFFFAOYSA-N
PubChem Compound ID	44428835
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[528766]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 528766	Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766	Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

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