Drug General Information
Drug ID	D01IDE
Former ID	DIB014877
Drug Name	E-5324
Drug Type	Small molecular drug
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Discontinued in Phase 2	[545733]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C26H34N4O2
Canonical SMILES	n1c(c(n(c1)CCCOc1c(NC(=O)NCCCC)c(ccc1)C)CC)c1ccccc1
CAS Number	CAS 141799-76-0
PubChem Compound ID	132377
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[533828]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545733	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004427)
Ref 533828	Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis. 1994 Jun;107(2):187-201.

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