Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01IDE
|
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| Former ID |
DIB014877
|
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| Drug Name |
E-5324
|
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| Drug Type |
Small molecular drug
|
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| Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Discontinued in Phase 2 | [1] | ||
| Company |
Eisai Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C26H34N4O2
|
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| Canonical SMILES |
n1c(c(n(c1)CCCOc1c(NC(=O)NCCCC)c(ccc1)C)CC)c1ccccc1
|
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| CAS Number |
CAS 141799-76-0
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004427) | ||||
| REF 2 | Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis. 1994 Jun;107(2):187-201. | ||||
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