Drug General Information
Drug ID	D01IFO
Former ID	DNC011063
Drug Name	6-(3-(trifluoromethyl)phenyl)picolinonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530989]
Structure		Download 2D MOL 3D MOL
Formula	C13H7F3N2
Canonical SMILES	C1=CC(=CC(=C1)C(F)(F)F)C2=CC=CC(=N2)C#N
InChI	1S/C13H7F3N2/c14-13(15,16)10-4-1-3-9(7-10)12-6-2-5-11(8-17)18-12/h1-7H
InChIKey	FYQRYAIHFASLNM-UHFFFAOYSA-N
PubChem Compound ID	49863205
Target and Pathway
Target(s)	Cathepsin S	Target Info	Inhibitor	[530989]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Tuberculosis
NetPath Pathway	Leptin Signaling Pathway
	IL2 Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentation
WikiPathways	Class I MHC mediated antigen processing & presentation
	Trafficking and processing of endosomal TLR
References
Ref 530989	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4507-10. Epub 2010 Jun 10.4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important.
Ref 530989	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4507-10. Epub 2010 Jun 10.4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important.

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