Drug Information

Drug General Information
Drug ID
D01JIO
Former ID
DIB009105
Drug Name
ZK-91587
Synonyms
SH-D515; 15beta, 16beta-Methylenemexrenone
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Phase 2 [533431]
Structure
Download
2D MOL

3D MOL
Formula
C25H32O5
Canonical SMILES
CC12CCC(=O)C=C1CC(C3C2CCC4(C3C5CC5C46CCC(=O)O6)C)C(=O)O<br />C
InChI
1S/C25H32O5/c1-23-7-4-14(26)10-13(23)11-16(22(28)29-3)20-17(23)5-8-24(2)21(20)15-12-18(15)25(24)9-6-19(27)30-25/h10,15-18,20-21H,4-9,11-12H2,1-3H3/t15-,16-,17+,18+,20-,21+,23+,24+,25+/m1/s1
InChIKey
YDIQJONNFLVNGD-FPMRONRSSA-N
CAS Number
CAS 84542-26-7
PubChem Compound ID
122017
PubChem Substance ID
10239905, 12013990, 29302488, 57339905, 78094779, 103830624, 104414829, 135076851
Target and Pathway
Target(s) Mineralocorticoid receptor Target Info Antagonist [533431], [551871]
KEGG Pathway Aldosterone-regulated sodium reabsorption
PathWhiz Pathway Kidney Function
WikiPathways ACE Inhibitor Pathway
References
Ref 533431ZK91587: a novel synthetic antimineralocorticoid displays high affinity for corticosterone (type I) receptors in the rat hippocampus. Life Sci. 1988;43(19):1537-43.
Ref 533431ZK91587: a novel synthetic antimineralocorticoid displays high affinity for corticosterone (type I) receptors in the rat hippocampus. Life Sci. 1988;43(19):1537-43.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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