Drug General Information
Drug ID	D01KEB
Former ID	DIB012621
Drug Name	MK-1293
Indication	Malaria [ICD10:B54]		Phase 3	[524642]
Structure		Download 2D MOL
Target and Pathway
Target(s)	insulin	Target Info	Modulator
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Oocyte meiosis
	Regulation of autophagy
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Regulation of actin cytoskeleton
	Insulin signaling pathway
	Insulin secretion
	Ovarian steroidogenesis
	Progesterone-mediated oocyte maturation
	Prolactin signaling pathway
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Type I diabetes mellitus
	Maturity onset diabetes of the young
	Aldosterone-regulated sodium reabsorption
	Prostate cancer
PANTHER Pathway	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascade
Pathway Interaction Database	Insulin Pathway
	Signaling events mediated by PTP1B
	Arf6 trafficking events
	Signaling events mediated by TCPTP
	FOXA2 and FOXA3 transcription factor networks
	ATF-2 transcription factor network
	Insulin-mediated glucose transport
	FOXA1 transcription factor network
PathWhiz Pathway	Insulin Signalling
	Pancreas Function
	Leucine Stimulation on Insulin Signaling
Reactome	Regulation of gene expression in beta cells
	Insulin processing
	Regulation of insulin secretion
	IRS activation
	Signal attenuation
	Insulin receptor signalling cascade
	Insulin receptor recycling
WikiPathways	Senescence and Autophagy in Cancer
	Differentiation Pathway
	Insulin Processing
	Nanoparticle triggered autophagic cell death
	Cardiac Progenitor Differentiation
	Adipogenesis
	AGE/RAGE pathway
	SREBP signalling
	Cori Cycle
	Synthesis, Secretion, and Deacylation of Ghrelin
	Signaling by Insulin receptor
	Regulation of beta-cell development
	Integration of energy metabolism
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 524642	ClinicalTrials.gov (NCT02059161) A Study of the Safety and Efficacy of MK-1293 Compared to Lantus in Participants With Type 1 Diabetes Mellitus (T1DM) (MK-1293-003). U.S. National Institutes of Health.

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