Drug Information

Drug General Information
Drug ID
D01KPV
Former ID
DAP000330
Drug Name
Fexofenadine
Synonyms
Carboxyterfenadine; Fexofendine; Terfenadine acid metabolite; Terfenadine carboxylate; F 9427; MDL 16455; Allegra (TN); Fastofen (TN); Fexofenadine (INN); Fexofenadine [INN:BAN]; Telfast (TN); Terfenadine-COOH; Terfenidine carboxylate, MDL 16455; Tilfur (TN); 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid; 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [468050], [534869]
Therapeutic Class
Antiallergic Agents
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C32H39NO4
InChI
InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)
InChIKey
RWTNPBWLLIMQHL-UHFFFAOYSA-N
CAS Number
CAS 83799-24-0
PubChem Compound ID
3348
PubChem Substance ID
9212, 5309243, 8152130, 11364860, 11367422, 11369984, 11372841, 11373946, 11378153, 11484933, 11488995, 11491736, 11492019, 11495728, 14835656, 17405051, 29222483, 46504676, 47953966, 48029199, 48029200, 49846688, 49878780, 50105687, 50105688, 53777594, 53787836, 57321745, 75782525, 85164717, 85209576, 85231056, 85789329, 90341422, 92304031, 93626300, 96024653, 103238871, 104303248, 117867878, 121361161, 124749753, 124880162, 124880163, 124891597, 125727652, 126525323, 126683996, 127278637, 127278638
ChEBI ID
ChEBI:5050
SuperDrug ATC ID
R06AX26
SuperDrug CAS ID
cas=083799240
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [535660], [537072]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 468050(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4819).
Ref 534869Comparative tolerability of second generation antihistamines. Drug Saf. 1999 May;20(5):385-401.
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 537072Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.

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