Drug General Information
Drug ID	D01MSM
Former ID	DNC012396
Drug Name	3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534270]
Structure		Download 2D MOL 3D MOL
Formula	C10H6N2O5
Canonical SMILES	C1=CC2=C(C=C1[N+](=O)[O-])C(=CC(=O)C(=O)N2)O
InChI	1S/C10H6N2O5/c13-8-4-9(14)10(15)11-7-2-1-5(12(16)17)3-6(7)8/h1-4,13H,(H,11,14,15)
InChIKey	QIUGYFFOPLNZSP-UHFFFAOYSA-N
PubChem Compound ID	10633414
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[534270]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[534270]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[534270]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Huntington's disease
	Alcoholismhsa04014:Ras signaling pathway
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
	Reelin signaling pathway
Reactome	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
References
Ref 534270	J Med Chem. 1996 Nov 8;39(23):4643-53.Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.
Ref 534270	J Med Chem. 1996 Nov 8;39(23):4643-53.Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

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