Drug Information

Drug General Information
Drug ID
D01MYO
Former ID
DNC003160
Drug Name
Fexaramine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539789]
Structure
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2D MOL

3D MOL
Formula
C32H36N2O3
InChI
InChI=1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1-3H3/b21-14+
InChIKey
VLQTUNDJHLEFEQ-KGENOOAVSA-N
CAS Number
CAS 574013-66-4
PubChem Compound ID
5326713
PubChem Substance ID
828933, 11060027, 14835454, 17396639, 39299521, 46505254, 50112913, 50226430, 50226431, 57309862, 85788208, 103461035, 104052461, 113905013, 123055391, 135228168, 135650259, 135698646, 137244939, 172917359, 204372590, 223445172, 241376002, 249617611, 252156613, 252450813, 252478858
Target and Pathway
Target(s) Bile acid receptor Target Info Inhibitor [551393]
KEGG Pathway Bile secretion
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterols
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid Pathway
References
Ref 539789(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2744).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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