Drug Information

Drug General Information
Drug ID
D01MZJ
Former ID
DCL000154
Drug Name
LR3001
Drug Type
Antisense drug
Indication Myeloid leukemia [ICD9: 208.9; ICD10:C92] Phase 2 [550342]
Therapeutic Class
Anticancer Agents
Company
Genta
Target and Pathway
Target(s) mRNA of Myb proto-oncogene protein Target Info [550612]
KEGG Pathway PI3K-Akt signaling pathway
HTLV-I infection
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database IL4-mediated signaling events
IL2 signaling events mediated by PI3K
AP-1 transcription factor network
C-MYB transcription factor network
Notch-mediated HES/HEY network
Reactome Factors involved in megakaryocyte development and platelet production
WikiPathways SIDS Susceptibility Pathways
EV release from cardiac cells and their functional effects
Hematopoietic Stem Cell Differentiation
Neural Crest Differentiation
miR-targeted genes in lymphocytes - TarBase
Factors involved in megakaryocyte development and platelet production
References
Ref 550342Pipeline report of Genta.
Ref 550612Genta obtains orphan drug designation for C-Myb Antisense (LR3001) in chronic myelocytic leukemia. Genta. 2005.

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