Drug Information

Drug General Information
Drug ID
D01NJI
Former ID
DAP001400
Drug Name
Mepyramine maleate
Synonyms
Anisopyradamine; Antihist; Enrumay; Histan; Histatex; Histine; Histosol; Minihist; Paramal; Pyma; Pymafed; Pyraninyl; Renstamin; Anthisan maleate; Component of Pyrdex; Diaminide maleate; Dorantamin maleate; Kriptin maleate; Mepiramine maleate; Mepyramine hydrogen maleinate; Mepyramine maleate salt; Midol Maximum Strength PMS; Neoantergan maleate; PYRILAMINE MALEATE; Paraminyl maleate; Prefrin A; Pyra maleate; Pyramal maleate; Pyranilamine m aleate; Pyranilamine maleate; Pyranisamine maleate; Pyrilamine maleate [USAN]; Pyrilamine maleate salt; Stangen maleate; Statomin maleate; Thylogen maleate; P 5514; Component of Endotussin-NN; Histavet-P; Neo-Antergan maleate; Pymafed (TN); Pyra-Maleate; Pyrilamine maleate (USP); Histavet-P (veterinary); PYRILAMINE MALEATE (SEE ALSO PYRILAMINE, CAS 91-84-9); N-Dimethylaminoethyl-N-p-methoxy-alpha-aminopyridine maleate; N-(dimethylaminoethyl)-N-(p-methoxyphenyl)-alpha-aminopyridine maleate; N-(Dimethylamino)ethyl-N-(p-methoxy)-.alpha.-aminopyridine maleate; N-p-Methoxybenzyl-N',N'-dimethyl-N-alpha-pyridylethylenediamine maleate; Pyridine, 2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]-, maleate (1:1); N,N-Dimethyl-N'-(4-methoxybenzyl)-N'-(2-pyridyl)ethylenediamine maleate; N-(p-me thoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine maleate; N-(p-methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine maleate; Pyridine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, maleate (1:1); N-(4-Methoxyphenyl)methyl-N inverted exclamation marka,Ninverted exclamation marka-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt; N-(p-Methoxybenzyl)-N',N'-dimethyl-N-.alpha.-pyridylethylenediamine maleate; N-(p-Methoxybenzyl)-N,N'-dimethyl-N-2-pyridyl-1,2-ethanediamine, maleic acid salt; N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine; N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt; N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine but-2-enedioate; N,N-dimethyl-N'-{[4-(methyloxy)phenyl]methyl}-N'-pyridin-2-ylethane-1,2-diamine (2Z)-but-2-enedioate; (Z)-but-2-enedioic acid; 1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1); 1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-, (Z)-2-butenedioate (1:1); 1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-, (Z)-2-butenedioate (1:1); 1,2-Ethanediamine, N1-((4-methoxyphenyl)methyl)-N2,N2-dimethyl-N1-2-pyridinyl-, (2Z)-2-butenedioate (1:1); 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine bimaleate; 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine maleate; 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine maleate (1:1); 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine maleate; 2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine bimaleate; 2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine maleate; 2786 R.P. maleate
Drug Type
Small molecular drug
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Approved [537515]
Therapeutic Class
Antiasthmatic Agents
Structure
Download
2D MOL

3D MOL
Formula
C21H27N3O5
Canonical SMILES
CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
InChI
1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
JXYWFNAQESKDNC-BTJKTKAUSA-N
CAS Number
CAS 59-33-6
PubChem Compound ID
5284451
PubChem Substance ID
70057, 855902, 8149511, 10321599, 11039284, 17405449, 24277797, 26611903, 26680596, 26747601, 26747602, 39317787, 47207321, 48414401, 48424022, 49854469, 50106737, 50106738, 50106739, 53777996, 56422415, 74505398, 87220220, 91011388, 92124194, 92125164, 92304336, 92307601, 99301263, 103770989, 103914089, 113862915, 121264371, 121361486, 121362835, 124637085, 124800889, 124800890, 134338608, 134340402, 134972293, 135697893, 144075206, 144207712, 144233404, 152090224, 162227138, 163564844, 172829020, 175266358
SuperDrug ATC ID
D04AA02; R06AC01
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537488], [537502], [537515]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 537515Antinociception induced by central administration of histamine in the formalin test in rats. Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54.
Ref 537488Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines. Arzneimittelforschung. 2009;59(5):243-7.
Ref 537502Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat. Inflamm Res. 2009 Jun 21.
Ref 537515Antinociception induced by central administration of histamine in the formalin test in rats. Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54.

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