Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01NTN
|
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| Former ID |
DNC005483
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| Drug Name |
3-(3,5-Dibromo-4-hexyloxy-phenyl)-propionic acid
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C15H20Br2O3
|
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| Canonical SMILES |
CCCCCCOC1=C(C=C(C=C1Br)CCC(=O)O)Br
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| InChI |
1S/C15H20Br2O3/c1-2-3-4-5-8-20-15-12(16)9-11(10-13(15)17)6-7-14(18)19/h9-10H,2-8H2,1H3,(H,18,19)
|
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| InChIKey |
FVDRTJXVCUAOCA-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thyroid hormone receptor alpha | Target Info | Inhibitor | [1] | |
| Thyroid hormone receptor beta-1 | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Thyroid hormone signaling pathwayhsa04080:Neuroactive ligand-receptor interaction | |||||
| Thyroid hormone signaling pathway | |||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor | ||||
| Reactome | Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway | ||||
| WikiPathways | Endochondral Ossification | ||||
| Nuclear ReceptorsWP706:SIDS Susceptibility Pathways | |||||
| Hematopoietic Stem Cell Differentiation | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | J Med Chem. 2005 May 5;48(9):3114-7.Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. | ||||
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