Drug Information

Drug General Information
Drug ID
D01OBV
Former ID
DNC000896
Drug Name
Luteolin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468268]
Structure
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2D MOL

3D MOL
Formula
C15H10O6
InChI
InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChIKey
IQPNAANSBPBGFQ-UHFFFAOYSA-N
PubChem Compound ID
5280445
PubChem Substance ID
4680, 597187, 7429738, 8145650, 8616273, 10318976, 10321223, 11108250, 11112366, 11112367, 11466898, 11468018, 11486576, 12015086, 14897817, 24896520, 25622156, 26725303, 26754151, 26754152, 26759067, 29204349, 39289568, 46500347, 47216891, 47291243, 47589108, 47589109, 48035258, 48035259, 48259375, 48259376, 48334626, 49698673, 49970086, 50124086, 50124087, 50979249, 53790299, 53800709, 56369288, 56463543, 57357740, 60766863, 74380610, 81041194, 85256900, 85279365, 85788780, 87561546
ChEBI ID
ChEBI:15864
Target and Pathway
Target(s) DNA topoisomerase I Target Info Inhibitor [535459]
Lyso-PAF: acetyl-CoA acetyltransferase Target Info Inhibitor [538004]
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 468268(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5215).
Ref 535459Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61.
Ref 538004Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm Res. 1996 Nov;45(11):546-9.

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