TTD | Drug: D01OIV

Drug General Information
Drug ID	D01OIV
Former ID	DIB021008
Drug Name	T-0509
Synonyms	RP333
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540773]
Structure		Download 2D MOL
Formula	C18H23NO5
InChI	InChI=1S/C18H23NO5/c1-23-17-6-3-12(9-18(17)24-2)7-8-19-11-16(22)13-4-5-14(20)15(21)10-13/h3-6,9-10,16,19-22H,7-8,11H2,1-2H3
InChIKey	DIPGFXJERHNAQQ-UHFFFAOYSA-N
PubChem Compound ID	173382
PubChem Substance ID	10257844, 16829708, 33497748, 78919890, 85209324, 113473776, 127740087, 135192146, 135651221, 229684913
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Agonist	[534301]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540773	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 533).
Ref 534301	Molecular characterization of pharmacological properties of T-0509 for beta-adrenoceptors. Eur J Pharmacol. 1996 Nov 21;315(3):363-7.

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Drug Information