Drug General Information |
Drug ID |
D01OYS
|
Former ID |
DIB002788
|
Drug Name |
Cyclolignan picropodophyllin
|
Synonyms |
PPP; IGF-1R inhibitor (cancer), Karolinska
|
Indication |
Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21]
|
Phase 1 |
[1]
|
Company |
Karolinska Institute
|
Target and Pathway |
Target(s) |
Insulin-like growth factor I receptor |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
HIF-1 signaling pathway
|
FoxO signaling pathway
|
Oocyte meiosis
|
Endocytosis
|
PI3K-Akt signaling pathway
|
AMPK signaling pathway
|
Focal adhesion
|
Adherens junction
|
Signaling pathways regulating pluripotency of stem cells
|
Long-term depression
|
Ovarian steroidogenesis
|
Progesterone-mediated oocyte maturation
|
Pathways in cancer
|
Transcriptional misregulation in cancer
|
Proteoglycans in cancer
|
Glioma
|
Prostate cancer
|
Melanoma
|
PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
Pathway Interaction Database
|
Plasma membrane estrogen receptor signaling
|
SHP2 signaling
|
IGF1 pathway
|
Posttranslational regulation of adherens junction stability and dissassembly
|
Integrins in angiogenesis
|
Stabilization and expansion of the E-cadherin adherens junction
|
Reactome
|
IRS-related events triggered by IGF1R
|
SHC-related events triggered by IGF1R
|
WikiPathways
|
Senescence and Autophagy in Cancer
|
Insulin Signaling
|
Endochondral Ossification
|
Focal Adhesion
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
Apoptosis
|
Signaling Pathways in Glioblastoma
|
TSH signaling pathway
|
MicroRNAs in cardiomyocyte hypertrophy
|
References |
REF 1 | Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation. Am J Cancer Res. 2011; 1(3): 356-361. |
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REF 2 | The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling. J Vasc Surg. 2007 Jul;46(1):108-15. |