TTD | Drug: D01PAC

Drug General Information
Drug ID	D01PAC
Former ID	DIB018160
Drug Name	[125I]L703,606
Synonyms	[125I]L703606; [125I]-L703,606
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540410]
Structure		Download 2D MOL
Formula	C27H29IN2
InChI	InChI=1S/C27H29IN2/c28-24-14-8-7-13-23(24)19-29-26-22-15-17-30(18-16-22)27(26)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-14,22,25-27,29H,15-19H2/t26-,27-/m1/s1/i28-2
InChIKey	WSLTYZVXORBNLB-BRXFWFLGSA-N
PubChem Compound ID	53326807
PubChem Substance ID	53801063, 124976390
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[533970]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540410	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3471).
Ref 533970	Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994 Jan;45(1):97-103.

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Drug Information