Drug General Information
Drug ID	D01RLF
Former ID	DNC011393
Drug Name	9H-beta-Carboline-3-carboxylic acid ethyl ester
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533546]
Structure		Download 2D MOL 3D MOL
Formula	C14H12N2O2
Canonical SMILES	CCOC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2
InChI	1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3
InChIKey	KOVRZNUMIKACTB-UHFFFAOYSA-N
PubChem Compound ID	105078
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[533546]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[533546]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[533546]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 533546	J Med Chem. 1983 Apr;26(4):499-503.beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.
Ref 533546	J Med Chem. 1983 Apr;26(4):499-503.beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.

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