Drug Information

Drug General Information
Drug ID
D01RVS
Former ID
DCL000472
Drug Name
AZD5985
Drug Type
Small molecular drug
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Discontinued in Phase 1 [548831]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C38H43Cl2N9O5S
Canonical SMILES
CCC1=C(NC(=O)C(=C1)NCC2=NC3=C(C=CC(=C3O2)Cl)Cl)C.CC(C)N<br />C1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)<br />(=O)C
InChI
1S/C22H28N6O3S.C16H15Cl2N3O2/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-3-9-6-12(16(22)20-8(9)2)19-7-13-21-14-10(17)4-5-11(18)15(14)23-13/h4-8,13-15,24-26H,9-12H2,1-3H3;4-6,19H,3,7H2,1-2H3,(H,20,22)
InChIKey
XOJHGEHJHFRZRW-UHFFFAOYSA-N
PubChem Compound ID
9811072
PubChem Substance ID
14767048, 44847056, 76127130, 134339076
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [550288]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 548831Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029299)
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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