Drug Information

Drug General Information
Drug ID
D01SYU
Former ID
DNCL001781
Drug Name
Turofexorate isopropyl
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Phase 1 [548483]
Company
Pfizer New York, NY
Structure
Download
2D MOL

3D MOL
Formula
C25H24F2N2O3
Canonical SMILES
CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(<br />=C(C=C4)F)F
InChI
1S/C25H24F2N2O3/c1-14(2)32-24(31)17-12-29(23(30)15-9-10-18(26)19(27)11-15)13-25(3,4)21-16-7-5-6-8-20(16)28-22(17)21/h5-12,14,28H,13H2,1-4H3
InChIKey
INASOKQDNHHMRE-UHFFFAOYSA-N
PubChem Compound ID
10026128
PubChem Substance ID
15007710, 22454421, 44143203, 58097730, 78432654, 85852616, 92729644, 96024964, 103591352, 123055418, 126671459, 135261047, 136349558, 136367689, 137275949, 137348407, 152258858, 160647707, 162038105, 162156117, 162202780, 163395032, 163843769, 165246682, 184825294, 189622847, 198989171, 202555789, 223386908, 223612979, 223676985, 223705224, 223850150, 226620161, 242060100, 248959552, 249866596, 250212671, 251971163, 252074945, 252160417, 252216607, 252438376
Target and Pathway
Target(s) Bile acid receptor Target Info Modulator [529912]
KEGG Pathway Bile secretion
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterols
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid Pathway
References
Ref 548483Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025892)
Ref 529912A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G543-52.

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