Drug General Information
Drug ID
D01TJM
Former ID
DIB001022
Drug Name
CTCE-9908
Synonyms
Anticancer therapy, Chemokine Therapeutics; CTCE-9908/0019
Indication Sarcoma [ICD9: 202.8; ICD10:C81-C86] Phase 1/2 [530179]
Company
Chemokine Therapeutics Corp; Chemokine Therapeutics
Structure
Download
2D MOL

3D MOL

Formula
C86H147N27O23
Canonical SMILES
c1(ccc(cc1)O)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@<br />@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CCCCN)C(C)C)CO)C<br />C(C)C)CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCCCNC(=O)[C@@H<br />](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N<br />C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CCCCN)C(C)C)CO)CC(C)C<br />)CO)Cc1ccc(cc1)O)CCCNC(=N)N)CCCNC(=N)N
CAS Number
CAS 1030384-98-5
PubChem Compound ID
Target and Pathway
Target(s) C-X-C chemokine receptor 4 Target Info Modulator [530179]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Axon guidance
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Pathways in cancer
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Axon guidance mediated by Slit/Robo
Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database S1P3 pathway
CXCR4-mediated signaling events
Syndecan-4-mediated signaling events
HIF-1-alpha transcription factor network
Ephrin B reverse signaling
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Hematopoietic Stem Cell Differentiation
HIV Life Cycle
Cardiac Progenitor Differentiation
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530179A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug;155(2):231-6.
Ref 530179A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug;155(2):231-6.

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