Drug General Information
Drug ID	D01UZT
Former ID	DNC012974
Drug Name	4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528080]
Structure		Download 2D MOL 3D MOL
Formula	C14H10ClN3
Canonical SMILES	C1=CC=NC(=C1)N2C=C(C=N2)C3=CC=C(C=C3)Cl
InChI	1S/C14H10ClN3/c15-13-6-4-11(5-7-13)12-9-17-18(10-12)14-3-1-2-8-16-14/h1-10H
InChIKey	NJMIDEUMQUSYDE-UHFFFAOYSA-N
PubChem Compound ID	44408653
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528080]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 528080	J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Ref 528080	J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

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