Drug General Information
Drug ID	D01VAP
Former ID	DIB010738
Drug Name	YM-430
Synonyms	YM-15430-1; YM-15430-2; YM-15430-3; YM-15430-4
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Phase 2	[534350]
Company	Yamanouchi Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(=C(NC(=C([C@H]1c1cc([N+](=O)[O-])ccc1)C(=O)OCCCCNC[C<br />@@H](COc1ccccc1)O)C)C)C(=O)OC
CAS Number	CAS 153192-22-4
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[534350]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 534350	Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6.
Ref 534350	Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6.

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