Drug Information

Drug General Information
Drug ID
D01WHI
Former ID
DIB020151
Drug Name
L023103
Synonyms
L 023103; L-023103
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539394]
Structure
Download
2D MOL

3D MOL
Formula
C30H33ClN6O5S
InChI
InChI=1S/C30H33ClN6O5S/c1-36(2)19-5-18-32-27(38)17-10-21-8-15-24(16-9-21)43(41,42)37(23-13-11-22(31)12-14-23)20-28(39)34-35-29-25-6-3-4-7-26(25)33-30(29)40/h3-4,6-9,11-16H,5,10,17-20H2,1-2H3,(H,32,38)(H,34,39)(H,33,35,40)
InChIKey
BUKWNCANUKACAQ-UHFFFAOYSA-N
PubChem Compound ID
6918778
PubChem Substance ID
16310680, 43530141, 74388518, 85229126, 103473598, 103629861, 104063544, 114788533, 123105837, 135650461, 139992271, 143106303, 170481061, 229389511, 246215291
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Antagonist [527891]
Oxytocin receptor Target Info Antagonist [527891]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contractionhsa04020:Calcium signaling pathway
cAMP signaling pathway
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
GPCR downstream signaling
References
Ref 539394(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2194).
Ref 527891Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists. J Med Chem. 2005 Dec 1;48(24):7882-905.

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