Drug Information

Drug General Information
Drug ID
D01WKR
Former ID
DIB019806
Drug Name
eGlu
Synonyms
EGLU; (s)-alpha-ethylglutamate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538877]
Structure
Download
2D MOL
Formula
C7H13NO4
InChI
InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1
InChIKey
QFYBYZLHPIALCZ-ZETCQYMHSA-N
PubChem Compound ID
5311079
PubChem Substance ID
7979150, 11056257, 11113827, 15364168, 26752001, 39340804, 47657024, 51810280, 57359348, 91746303, 114155217, 129017282, 132558183, 135650224, 162221553, 162449005, 170485677, 226540706, 241182026, 242254865
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Antagonist [525820]
Metabotropic glutamate receptor 2 Target Info Antagonist [525820]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
References
Ref 538877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1400).
Ref 525820Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6.

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