Drug General Information
Drug ID	D01XWL
Former ID	DNC012400
Drug Name	3-Hydroxy-8-methyl-1H-benzo[b]azepine-2,5-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534270]
Structure		Download 2D MOL 3D MOL
Formula	C11H9NO3
Canonical SMILES	CC1=CC2=C(C=C1)C(=CC(=O)C(=O)N2)O
InChI	1S/C11H9NO3/c1-6-2-3-7-8(4-6)12-11(15)10(14)5-9(7)13/h2-5,13H,1H3,(H,12,14,15)
InChIKey	HJKATLKAMYKFOH-UHFFFAOYSA-N
PubChem Compound ID	126810
Target and Pathway
Target(s)	NMDA receptor subunit NR1	Target Info	Inhibitor	[534270]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[534270]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[534270]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholismhsa04014:Ras signaling pathway
	Dopaminergic synapse
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
	Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	SIDS Susceptibility Pathways
	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
References
Ref 534270	J Med Chem. 1996 Nov 8;39(23):4643-53.Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.
Ref 534270	J Med Chem. 1996 Nov 8;39(23):4643-53.Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

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