TTD | Drug: D01XZI

Drug General Information
Drug ID	D01XZI
Former ID	DIB018060
Drug Name	(-)-trans-H2-PAT
Synonyms	H2-Pat
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538724]
Structure		Download 2D MOL
Formula	C18H21N
InChI	InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m0/s1
InChIKey	DXJUCAUQIHNOAF-WMZOPIPTSA-N
PubChem Compound ID	10015055
PubChem Substance ID	14995691, 24440403, 44107150, 47434850, 48029659, 76765870, 92729813, 135088857, 135650435, 136352129, 229744204
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Antagonist	[526358]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538724	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1212).
Ref 526358	J Pharmacol Exp Ther. 2002 Jul;302(1):328-36.A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.

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Drug Information