Drug Information

Drug General Information
Drug ID
D01YEN
Former ID
DIB020031
Drug Name
ibotenate
Synonyms
ibotenic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538849]
Structure
Download
2D MOL
Formula
C5H6N2O4
InChI
InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
InChIKey
IRJCBFDCFXCWGO-UHFFFAOYSA-N
PubChem Compound ID
1233
PubChem Substance ID
12783, 565789, 5455818, 6240816, 7979560, 8140585, 8151047, 15363851, 17405212, 24277994, 24439578, 26751670, 29204271, 47365404, 47736693, 47736711, 49987522, 50104365, 50104366, 53777757, 56406882, 56463509, 57320830, 79577662, 85209396, 85231090, 90341316, 91704578, 91746333, 92304093, 99300599, 103199832, 103918448, 104297143, 118695783, 119526463, 121361487, 124749888, 124799290, 124880423, 124880424, 125539446, 128209285, 132511300, 134982726, 135652693, 136350327, 137261962, 140862532, 143856972
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Agonist [525911]
Metabotropic glutamate receptor 5 Target Info Agonist [525911]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathwayhsa04020:Calcium signaling pathway
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
References
Ref 538849(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1371).
Ref 525911Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.

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