TTD | Drug: D01YTS

Drug General Information
Drug ID	D01YTS
Former ID	DIB019053
Drug Name	CAA0225
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541660]
Structure		Download 2D MOL
Formula	C28H29N3O5
InChI	InChI=1S/C28H29N3O5/c32-22-13-11-19(12-14-22)15-16-29-27(34)24-25(36-24)28(35)31-23(17-20-7-3-1-4-8-20)26(33)30-18-21-9-5-2-6-10-21/h1-14,23-25,32H,15-18H2,(H,29,34)(H,30,33)(H,31,35)/t23-,24-,25-/m0/s1
InChIKey	ZMZQYVMNDRBKLO-SDHOMARFSA-N
PubChem Compound ID	50909779
PubChem Substance ID	111978100, 163685680, 178103146, 193879769
Target and Pathway
Target(s)	Cathepsin L	Target Info	Inhibitor	[529990]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Proteoglycans in cancer
	Rheumatoid arthritis
NetPath Pathway	IL4 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Collagen degradation
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentation
WikiPathways	Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 541660	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6532).
Ref 529990	Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis. Biol Pharm Bull. 2009 Mar;32(3):475-9.

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Drug Information