Drug Information

Drug General Information
Drug ID
D02AOD
Former ID
DIB003651
Drug Name
HF-0220
Synonyms
Cytoprotective steroid (Alzheimer's disease), Newron; Prostaglandin D synthase stimulator (Alzheimer's disease), Newron; Prostaglandin J2 synthesis stimulator (Alzheimer's disease), Newron; Cytoprotective steroid (Alzheimer's disease), Hunter-Fleming; Prostaglandin D synthase stimulator (Alzheimer's disease), Hunter-Fleming; Prostaglandin J2 synthesis stimulator (Alzheimer's disease), Hunter-Fleming
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2 [521861]
Company
Hunter-Fleming Ltd
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[C@H]12[C@H]([C@H]3[C@](CC2)(C(=O)CC3)C)[C@H](C[C@@H]2[<br />C@@]1(CC[C@@H](C2)O)C)O
Target and Pathway
Target(s) Glutathione S-transferase Target Info Stimulator [550953]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
WikiPathways Arachidonic acid metabolism
Aryl Hydrocarbon Receptor
Integrated Pancreatic Cancer Pathway
References
Ref 521861ClinicalTrials.gov (NCT00357357) European Study of HF0220 in Mild to Moderate Alzheimer's Disease Patients. U.S. National Institutes of Health.
Ref 550953US patent application no. 2009,0062,529, Multi-cyclic compounds.

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