Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02AUB
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| Former ID |
DCL000069
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| Drug Name |
Bimosiamose
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| Synonyms |
TBC 1269; TBC-1269
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| Drug Type |
Small molecular drug
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| Company |
Encysive Pharma
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| Structure |
|
Download2D MOL |
|||
| Formula |
C46H54O16
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| Canonical SMILES |
C1=CC(=CC(=C1)CC(=O)O)C2=C(C=CC(=C2)CCCCCCC3=CC(=C(C=C3<br />)OC4C(C(C(C(O4)CO)O)O)O)C5=CC(=CC=C5)CC(=O)O)OC6C(C(C(C<br />(O6)CO)O)O)O
|
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| InChI |
1S/C46H54O16/c47-23-35-39(53)41(55)43(57)45(61-35)59-33-15-13-25(19-31(33)29-11-5-9-27(17-29)21-37(49)50)7-3-1-2-4-8-26-14-16-34(60-46-44(58)42(56)40(54)36(24-48)62-46)32(20-26)30-12-6-10-28(18-30)22-38(51)52/h5-6,9-20,35-36,39-48,53-58H,1-4,7-8,21-24H2,(H,49,50)(H,51,52)/t35-,36-,39-,40-,41+,42+,43+,44+,45+,46+/m1/s1
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| InChIKey |
RYWCQJDEHXJHRI-XJMXIVSISA-N
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| CAS Number |
CAS 187269-40-5
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | E-selectin | Target Info | Inhibitor | [536136], [536502], [536763] | |
| Pathway Interaction Database | Thromboxane A2 receptor signaling | ||||
| Glucocorticoid receptor regulatory network | |||||
| ATF-2 transcription factor network | |||||
| References | |||||
| Ref 536136 | Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial. Pulm Pharmacol Ther. 2006;19(4):233-41. Epub 2005 Sep 1. | ||||
| Ref 536502 | The pharmacokinetics of subcutaneously injected Bimosiamose disodium in healthy male volunteers. Biopharm Drug Dispos. 2007 Dec;28(9):475-84. | ||||
| Ref 536763 | Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. Shock. 2008 Apr;29(4):475-82. | ||||
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