Drug Information

Drug General Information
Drug ID
D02CGC
Former ID
DCL000270
Drug Name
Sorbinil
Synonyms
SBI; Sorbinilo; Sorbinilum; Sorbinilo [Spanish]; Sorbinilum [Latin]; CP 45634; CP-45634; Sorbinil (USAN/INN); D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione; (4S)-6-fluoro-2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolidine]-2',5'-dione; (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
Drug Type
Small molecular drug
Indication Diabetic cataract [ICD10:E10.36, E11.36] Terminated [542439], [544510]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C11H9FN2O3
InChI
InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
InChIKey
LXANPKRCLVQAOG-NSHDSACASA-N
CAS Number
CAS 68367-52-2
PubChem Compound ID
337359
PubChem Substance ID
464383, 592669, 7890393, 7979348, 8898992, 12012698, 12016145, 15121785, 29215399, 37528353, 46504981, 46509502, 47207554, 48416546, 57401740, 74547229, 81066946, 87350465, 92098531, 103165545, 104540744, 104828809, 121360915, 128553726, 134338927, 134339157, 135009326, 137004922, 139060526, 141287583, 144205232, 160965885, 163726552, 170466611, 172919578, 175612299, 178103987, 179150924, 184547797, 198935949, 223454546, 226432735, 241120591
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [536032], [537789]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 542439(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7415).
Ref 544510Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000008)
Ref 536032Recent clinical experience with aldose reductase inhibitors. J Diabetes Complications. 1992 Jan-Mar;6(1):39-44.
Ref 537789A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy. Diabetes. 1983 Oct;32(10):938-42.

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