Drug Information

Drug General Information
Drug ID
D02CPP
Former ID
DNCL003781
Drug Name
TAK-438
Synonyms
Vonoprazan
Drug Type
Small molecular drug
Indication Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] Phase 3 [525119]
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C21H20FN3O6S
Canonical SMILES
CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=CC(<br />=O)O)C(=O)O
InChI
1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey
ROGSHYHKHPCCJW-WLHGVMLRSA-N
PubChem Compound ID
45375887
PubChem Substance ID
93367306, 120288094, 135267184, 152258678, 160647514, 160691163, 161005268, 163642818, 172232559, 172919603, 186014845, 198985140, 223471405, 224185500, 226087996, 226553222, 226553224, 252091142, 252160616, 252216361
Target and Pathway
Target(s) H+ K+ ATPase Target Info Modulator
References
Ref 525119ClinicalTrials.gov (NCT02388724) Efficacy and Safety of Oral Once-Daily Vonoprazan (TAK-438) in Patients With Erosive Esophagitis. U.S. National Institutes of Health.

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