Drug Information

Drug General Information
Drug ID
D02DEF
Former ID
DIB020111
Drug Name
JNJ-42153605
Synonyms
JNJ 42153605
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541463]
Structure
Download
2D MOL
Formula
C22H23F3N4
InChI
InChI=1S/C22H23F3N4/c23-22(24,25)20-18(10-13-29-19(14-15-6-7-15)26-27-21(20)29)28-11-8-17(9-12-28)16-4-2-1-3-5-16/h1-5,10,13,15,17H,6-9,11-12,14H2
InChIKey
BQAVZGJJQFJSMW-UHFFFAOYSA-N
PubChem Compound ID
49765871
PubChem Substance ID
103022204, 121101140, 135693596, 137127317, 163331911, 163348112, 178102935, 224604513, 227034096, 247621864
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator (allosteric modulator) [532084]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541463(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6317).
Ref 532084Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor. JMed Chem. 2012 Oct 25;55(20):8770-89.

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