Drug Information

Drug General Information
Drug ID
D02DKX
Former ID
DIB020222
Drug Name
LK 204-545
Synonyms
LK-204545
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540842]
Structure
Download
2D MOL
Formula
C25H32N4O6
InChI
InChI=1S/C25H32N4O6/c26-14-19-13-23(34-12-11-33-16-18-1-2-18)7-8-24(19)35-17-22(31)15-27-9-10-28-25(32)29-20-3-5-21(30)6-4-20/h3-8,13,18,22,27,30-31H,1-2,9-12,15-17H2,(H2,28,29,32)
InChIKey
VAWYRUMIUGPAEX-UHFFFAOYSA-N
PubChem Compound ID
5311116
PubChem Substance ID
7979390, 11056281, 15406259, 39340835, 79718673, 85209793, 103489337, 114155304, 131328142, 135650529, 164161582, 239140326
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [525440]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540842(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 544).
Ref 525440LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5.

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