Drug Information

Drug General Information
Drug ID
D02EYG
Former ID
DCL000553
Drug Name
Linagliptin
Synonyms
Ondero; BI 1356; BI-1356; Ondero (TN); BI-1356-BS; (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Approved [541464], [551882]
Company
Boehringer Ingelheim
Structure
Download
2D MOL

3D MOL
Formula
C25H28N8O2
InChI
InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
InChIKey
LTXREWYXXSTFRX-QGZVFWFLSA-N
CAS Number
CAS 668270-12-0
PubChem Compound ID
10096344
PubChem Substance ID
15083733, 22505980, 29196126, 39156222, 56310616, 80795936, 103537922, 104097872, 124490306, 124772145, 126626882, 126665800, 134345106, 135257632, 135693249, 136367897, 137171672, 141692239, 144116143, 152090598, 152134670, 152159563, 152258162, 160644541, 160645740, 160646999, 162011748, 162198501, 164020949, 164193945, 164228213, 164761585, 172653134, 174006340, 174530256, 175267212, 175427132, 178102936, 184817874, 198992878, 223377286, 223554902, 223678280, 223704799, 226523537, 241125887, 242588098, 249072929, 249737177, 251971307
SuperDrug ATC ID
A10BH05
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [537022], [550386]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 541464(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6318).
Ref 551882Clinical pipeline report, company report or official report of Boehringer Ingelheim.
Ref 537022Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.
Ref 550386Boehringer Ingelheim. Product Development Pipeline. June 2 2009.

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