Drug Information

Drug General Information
Drug ID
D02FCY
Former ID
DIB020479
Drug Name
NAAG
Synonyms
N-acetylaspartylglutamate; NAAG; spaglumic acid; isospaglumic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538881]
Structure
Download
2D MOL
Formula
C11H16N2O8
InChI
InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1
InChIKey
OPVPGKGADVGKTG-BQBZGAKWSA-N
PubChem Compound ID
188803
PubChem Substance ID
7980673, 8150014, 10669851, 11112559, 11113480, 11335837, 11361076, 11363293, 11365855, 11368417, 11371698, 11374703, 11376579, 11462048, 11467119, 11468239, 11485238, 11486787, 11489387, 11490575, 11492688, 11494213, 11537717, 14825413, 26612503, 26680122, 26751698, 33510452, 47216778, 47216779, 47736484, 47810759, 47959745, 76680351, 85182292, 91011602, 92126028, 99301750, 103913863, 104171316, 113444559, 124636732, 124882459, 128844339, 135651520, 136930122, 142202893, 144075620, 162222804, 164174696
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Agonist [525820]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538881(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1405).
Ref 525820Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6.

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