Drug General Information
Drug ID	D02FXS
Former ID	DNC013000
Drug Name	3-carboxy-6-ethyl-4-quinolone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528134]
Structure		Download 2D MOL 3D MOL
Formula	C12H11NO3
Canonical SMILES	CCC1=CC2=C(C=C1)NC=C(C2=O)C(=O)O
InChI	1S/C12H11NO3/c1-2-7-3-4-10-8(5-7)11(14)9(6-13-10)12(15)16/h3-6H,2H2,1H3,(H,13,14)(H,15,16)
InChIKey	RESVKOSPFKHQBK-UHFFFAOYSA-N
PubChem Compound ID	721200
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528134]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528134]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528134]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[528134]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 528134	J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.
Ref 528134	J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.