Drug Information

Drug General Information
Drug ID
D02GBZ
Former ID
DIB012655
Drug Name
Tau phosphorylation inhibitors
Synonyms
Tau phosphorylation inhibitors (Alzheimer's disease); Tau phosphorylation inhibitors (Alzheimer's disease), ProQinase
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Investigative [552022]
Company
ProQinase GmbH
Structure
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2D MOL

3D MOL
Canonical SMILES
n1cc(c(c2c1oc1c2cc(cc1)O)c1ccccc1)O
Target and Pathway
Target(s) Microtubule-associated protein tau Target Info Inhibitor [531616]
KEGG Pathway MAPK signaling pathway
Alzheimer's disease
NetPath Pathway IL2 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database LPA receptor mediated events
Reelin signaling pathway
Reactome Caspase-mediated cleavage of cytoskeletal proteins
WikiPathways Notch Signaling Pathway
IL-2 Signaling Pathway
MAPK Signaling Pathway
Copper homeostasis
Kit receptor signaling pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Alzheimers Disease
Regulation of Microtubule Cytoskeleton
Apoptotic execution phase
IL-5 Signaling Pathway
References
Ref 552022Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes. Bioorg Med Chem Lett. 2005 Feb 1;15(3):823-5.
Ref 531616Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7.

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