Drug Information

Drug General Information
Drug ID
D02GOH
Former ID
DNC006015
Drug Name
AM-404
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534262]
Structure
Download
2D MOL

3D MOL
Formula
C26H37NO2
Canonical SMILES
CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)O
InChI
1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6+,10-9+,13-12+,16-15+
InChIKey
IJBZOOZRAXHERC-CGRWFSSPSA-N
PubChem Compound ID
6604822
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [529838]
Cannabinoid receptor 1 Target Info Inhibitor [534262]
Fatty-acid amide hydrolase Target Info Inhibitor [529838]
BioCyc Pathway Anandamide degradation
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04723:Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signalingP05728:Anandamide degradation
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 534262J Med Chem. 1996 Oct 25;39(22):4515-9.Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
Ref 529838J Med Chem. 2008 Dec 25;51(24):7800-5.New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.
Ref 534262J Med Chem. 1996 Oct 25;39(22):4515-9.Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.